PDG74 AVAILABILITY OF FDA-APPROVED SURROGATE MARKERS IN REAL-WORLD DATA

Measuring Real-World Data Availability

This paper examines how server marketing claims of high reliability (e.g., 99.999%) stack up against real world data measurements. Our goals were to: measure discretionary NFS data availability, compare data availability between standalone and clustered systems, and draw some conclusions about best practices for customers. We explain our methodology for measuring, filtering, and categorizing av...

the tragedy of modern man in arthur millers world

what miller wants is a theatre of heightened consciousness. he speaks of two passions in a man, the passion to "feel" and the passion "know". he belives that we can have more of the latter. he says: drama is akin to the other inventions of man in that it ought to help us know more and not merely to spend our feelings. the writing of the crucible shows us that he is trying to give more heightene...

investigation of (meta)discourse markers in elt coursebooks

the present study aimed to investigate representation of discourse markers and metadiscourse markers in conversations and readings of general elt coursebook series used in the language centers of iran. to this aim, four elt coursebooks popularly taught in language centers of this country were analyzed based on fung and carter’s (2007) framework regarding discourse markers and hyland’s (2005) fr...

FDA-Approved Drugs to Treat Schizophrenia.

Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study

BACKGROUND The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about the medical product's actual clinical effect. This study aims to compare the treatment effects among pivotal trials supporting FDA approval of novel therapeutics based on surrogat...